The Yerkes Research Center is home to seven service cores, which help make the Center a specialized facility that serves as a resource to many. From offering state-of-the-art genetic information production and analysis to housing world-class imaging technology, such cutting-edge technology coupled with the expertise of our researchers helps make Yerkes an internationally recognized leader in biomedical and behavioral studies with nonhuman primates. Explore our service cores to learn how our scientific expertise and specialized facilities and equipment for research with nonhuman primates are advancing science and improving health.
With more than 20 years of experience providing immunoassay determinations for investigators, the Yerkes Biomarkers Core offers a range of technologies including radioimmunoassay, ELISA, bioassay and liquid chromatography-mass spectrometry to identify and quantify biomolecules in tissues such as blood and plasma. The laboratory currently provides determinations on more than 60 compounds validated for nonhuman primates, humans and some other mammalian species.
The Comparative AIDS Core is a vital component of the expanding Yerkes research programs in AIDS-related studies. The Core is designed to provide oversight and coordination for these studies, as well as the necessary technical, laboratory and animal research support. Currently, the Core includes all the non-investigator assigned sooty mangabeys, as well as a large number of rhesus and pigtailed macaques. Over the past five years, the Core has provided just under 4,000 nonhuman primate samples to Yerkes Core and Affiliate scientists.
The Molecular Pathology Core in the Yerkes Division of Pathology is a service laboratory that provides research and diagnostic support to researchers and veterinary pathologists at Yerkes, Emory and other institutions and universities across the United States. Services we offer are immunohistochemistry and insitu hybridization assays for various nonhuman primate pathogens, including viruses and bacteria, and cell markers. Core staff members also help researchers design research protocols to incorporate these molecular pathology techniques.
This National Primate Research Center-sponsored resource to all investigators offers DNA from a range of nonhuman primate species. The Nonhuman Primate DNA Bank contains samples from related and unrelated animals within more than 10 species, including Chinese, Japanese and Indian rhesus macaques, pig-tailed macaques, baboons, chimpanzees, marmosets and sooty mangabeys. To request samples or for more informaiton, contact Dr. Steve Bosinger at the Yerkes Research Center.
The Yerkes National Primate Research Center Nonhuman Primate Genomics Core (GenCore) is a service laboratory that provides researchers at Yerkes, the Emory Vaccine Center (EVC) and the greater Emory community with access to cutting-edge, high-throughput genomic technologies, including Next Generation sequencing (NGS) and Microarray gene expression analysis. The GenCore, which features an Illumina HiSeq1000 System, an Affymetrix GeneChip platform and an Agilent Bioanalyzer, offers a diverse set of genomic assays, including NGS applications such as RNAseq, targeted resequencing, ChIP-seq and miRNA sequencing. The GenCore provides a start-to-finish solution, assisting in pre-experimental consultation, assay design, sample preparation, nucleic acid quality assessment and bioinformatics analysis. For more information, please contact Dr. Steve Bosinger.
The National Institutes of Health (NIH) Tetramer Core Facility, established in 1999 at the Yerkes Research Center, provides custom synthesis and distribution of soluble MHC-peptide tetramer reagents that can be used to stain antigen-specific T cells. In addition to Class I MHC tetramer production, the NIH Tetramer Facility also provides human and mouse CD1d tetramers and custom class II MHC reagents for four distinct HLA-DR alleles.
The mission of the THDMR is to facilitate basic and preclinical applications of the transgenic Huntington’s disease (HD) monkey model to advance scientific knowledge and the discovery of a cure for HD. Supported by the National Institutes of Health (NIH), the Transgenic Huntington’s Disease Monkey Resource (THDMR) is located at the Yerkes National Primate Research Center, Emory University.
The Yerkes Virology Core is a service laboratory providing necessary support for the management of the Yerkes macaque and mangabey colonies, through the use of serological and molecular testing for viruses. This management aspect includes the maintenance of the specific pathogen-free (SPF) rhesus macaque colony. Additionally, the Virology Core provides support for experimental studies ongoing at the Yerkes Research Center, Emory University, as well as outside the University. The functions of the Virology Core also include the management of the BSL3 facilities at the Yerkes Research Center and the management of the radiation facilities.
The Yerkes Imaging Core offers state-of-the-art imaging capabilities for non-invasive studies of the anatomy, physiology and function of nonhuman primate and rodent brains. The Yerkes Imaging Core provides technology allowing researchers to see cell damage in a living brain, to make earlier diagnoses and to better answer questions surrounding the studies of neurophysiology, neuroscience, neurology and neurodegenerative diseases.
In addition to offering MRI and PET scanning capabilities, the Yerkes Imaging Core, housed in the Yerkes Neuroscience Facility, offers electronic and mechanical workshops, premier computation resources, in-house animal facilities and veterinary support during imaging studies.